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支原体预防与清除利器,PlasmocinTM prophylactic优惠促销

作者:上海研卉生物科技有限公司 2013-07-09T11:57 (访问量:6964)

上海研卉生物支原体预防与清除利器,PlasmocinTM prophylactic优惠促销

支原体预防与清除利器,支原体清除,支原体预防,Mycoplasma Removal Agent
产品优势:1,预防支原体、细菌、真菌污染
2,只需2周即可清除支原体污染
3,不会影响细胞本身代谢
4, 不会重新感染(从其他细胞释放的)支原体

Plasmocin™

Mycoplasma Removal Agent

Plasmocin™ is used to

cure cell lines infected by mycoplasma

and related cell wall-less bacteria.


Plasmocin

Plasmocin™ can also be used as a routine addition in liquid media toprevent mycoplasma and more generally bacterial contamination in smalland large animal cell cultures.

Plasmocin™ is a well-established antimycoplasma reagent. It contains two bactericidal components strongly active against mycoplasmas that allow their elimination in only 2 weeks.
The first component acts on the protein synthesis machinery while the second acts on the DNA replication. These two specific and separate targets are found only in mycoplasmas and many other bacteria and are completely absent in eukaryotic cells.

Warning: InvivoGen's anti-mycoplasma products are suitable for research purposes only, and not for human or animal care.

Plasmocin™ prophylactic
2.5 mg/ml (Plasmocin™ Prophylactic)

货号:ant-mpp
支原体预防报价:1372元/25 mg (10 x 1 ml)

Plasmocin™ treatment

货号:ant-mpt
25 mg/ml (Plasmocin™Treatment)
支原体清除报价:2114元/50 mg (2 x 1 ml)

Comparison of the most common anti-mycoplasma agents[1-3]

对照表

Product Supplier Treatment Ease of use Efficacy Cytotoxicity Resistance
BM-Cyclin Roche 3 weeks - +++ + +/-
Ciprobay Bayer 12 to 20 days + ++ +/- +
MRA ICN 1 to 2 weeks + ++ +/- +
Plasmocin InvivoGen 2 weeks + +++ +/- -

Antibiotics commonly used in cell culture are inactive on mycoplasma (e.g. penicillins and streptomycin). Three classes of antibiotics have been shown to kill mycoplasma at relatively low concentrations: tetracyclines, macrolides and quinolones. Tetracyclines and macrolides block the protein synthesis by interfering with ribosome translation, while quinolones inhibit the replication of bacterial DNA.
Several antibiotics are commercially available for the removal of mycoplasma: BM-cyclin (Roche) contains a macrolide and a tetracycline, Ciprobay (Bayer, available only with a prescription) and MRA (ICN) are both quinolones. Plasmocin™ is the only antimycoplasma reagent that combines a macrolide and a quinolone. Unlike BM-Cyclin that requires the sequential and cyclic use of 2 antibiotics, Plasmocin™ is ready-to-use and can be added to the culture medium directly. Furthermore, the 2 antibiotics in Plasmocin™ act on separate targets blocking protein synthesis and DNA replication, whereas the 2 antibiotics in BM-Cyclin are both inhibitors of protein synthesis. Therefore, Plasmocin™ is more effective in removing mycoplasma and prevents the appearance of resistant strains. In contrast to other anti-mycoplasma compounds, Plasmocin™ is active on both free mycoplasma as well as intracellular forms. This advantage is conferred by one component of Plasmocin™ which is actively transported into mammalian cells. It ensures that following treatment with Plasmocin™ a cell culture is not reinfected by mycoplasma released from intracellular compartments of infected cells. To date, no consistent and permanent alterations that affect the eukaryotic cells during and after the treatment have been detected[1].

1. Uphoff CC, Drexler HG., 2005. Eradication of mycoplasma contaminations. Methods Mol Biol. 290:25-34.
2. Somasundaram C. et al., 1992. Use of ciprofloxacin and BM-Cyclin in mycoplasma decontamination.In Vitro Cell Dev Biol. 28A(11-12):708-10
3. Drexler HG. et al., 1994. Treatment of mycoplasma contamination in a large panel of cell cultures. In vitro Cell Dev Biol Anim. 30A(5):344-7

参考文献:

Recent articles using Plasmocin™

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